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KMID : 0381219710030110769
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Journal of RIMSK
1971 Volume.3 No. 11 p.769 ~ p.774
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EOSINOPHILIA AND ALLERGY
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Abstract
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The skin window technique according to Rebuck was used as means of study on mechanism of local eosinophilia in allergy, The following results were obtained.
Histamine, bradykinin, compound48/30 a proteolytic enzyme, pronase and sialic acid were not eosinophilotactic. Hoist dust allergen extract. produced a slight eosinophilia in all of the cases with house dust allergy examined. Anti-human rG "t serum, human -human G complex, aggregate-1 human rG, aggregated anti rG. serum and aggregated were not successful articles were not successful in eosinophilic response, The negative results were also obtained by application- of anti-human 1A rabbit serum, human TA,-antihuman r complex, aggregated TA, aggregated anti iA and aggregated tA-anti-iA complex. Administration of anti-human 7E rabbit set urn showed a marked eosinophilic reaction, All of the cases examined revealed eosinophilic response when the undiluted antiserum was used, and positive reaction was produced in approximately 50 per cent of the case examined with 1: 10 dilution. There was no difference in frequency of positive response among extrinsic, intrinsic allergy and normal non-allergic individual. "The higher the concentration of the antiserum, the intensity of local eosinophilia increased.
An accumulation of eosinophilia, appeared between 1 and 3 hours after- administration, The intensity of eosinophilic response in shin the window was neither influenced by administration of antihistamine nor correlated with the intensity 0f skin reaction with anti-human, rabbit serum.
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